Dr Rahul Bhargava

Amyloidosis

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Frequently Asked Questions (FAQ) :

Commonly affected organs include the kidneys, heart, liver, spleen, nerves, and gastrointestinal tract.

AL amyloidosis is caused by the abnormal production of light chain proteins by plasma cells, which form amyloid deposits. It is often associated with multiple myeloma.

AA amyloidosis is secondary to chronic inflammatory diseases, infections, or malignancies and involves the deposition of serum amyloid A protein.

Hereditary amyloidosis is caused by inherited mutations in specific genes, leading to abnormal amyloid protein production. Transthyretin (TTR) amyloidosis is the most common form.

Wild-type ATTR amyloidosis occurs due to the accumulation of normal transthyretin protein in elderly individuals, primarily affecting the heart.

Dialysis-related amyloidosis is caused by the accumulation of beta-2 microglobulin in patients undergoing long-term dialysis.

What is Amyloidosis ?

Amyloidosis is a rare and serious disease that occurs when an abnormal protein, called amyloid, builds up in organs and tissues throughout the body. This accumulation can interfere with normal function and cause damage. The amyloid deposits can affect various organs, including the heart, kidneys, liver, spleen, nervous system, and digestive tract.

Causes of Amyloidosis :

Amyloidosis occurs due to the misfolding of proteins that then aggregate into insoluble amyloid fibrils. The specific causes vary depending on the type of amyloidosis:

Types of Amyloidosis :

Symptoms of Amyloidosis :

The symptoms of amyloidosis can vary widely depending on the organs affected. Common symptoms include:

Diagnosis of Amyloidosis :

Diagnosing amyloidosis involves a combination of medical history, physical examination, and specialized tests, including:

Treatment Options :

Treatment for amyloidosis depends on the type and severity of the disease, as well as the organs affected. Common treatments include:

Cost of Treatment and Stay in India :

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