Dr Rahul Bhargava Haematologist

MBBS, MD, DM (Clinical Haematology)

Principal Director & Chief Hematology at Fortis Hospital

MBBS, MD, DM (Clinical Haematology)

Principal Director & Chief Hematology at Fortis Hospital

Myeloproliferative Disorders

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Frequently Asked Questions (FAQ) :

Risk factors include age, family history of blood disorders, and exposure to certain chemicals or radiation.

While MPDs are chronic conditions, they can often be managed effectively with treatment. In some cases, a bone marrow transplant may offer a potential cure.

Patients should maintain a healthy diet, exercise regularly, and avoid smoking or exposure to toxins. Regular monitoring and following the prescribed treatment plan are essential.

Regular check-ups are crucial. The frequency will depend on the severity of your condition and the treatment plan.

Yes, with proper precautions and following international travel guidelines, it is safe. Indian hospitals are well-equipped with COVID-19 safety protocols.

Overview of Myeloproliferative Disorders

Myeloproliferative Disorders (MPDs) are a group of rare blood cancers where bone marrow cells that produce blood cells develop and function abnormally. This leads to an overproduction of one or more types of blood cells. The most common types of MPDs include Polycythemia Vera, Essential Thrombocythemia, and Myelofibrosis.

Causes of Myeloproliferative Disorders

The exact cause of Myeloproliferative Disorders remains unclear, but genetic mutations, particularly the JAK2 gene mutation, are found in a significant number of patients. Other factors may include exposure to radiation, certain chemicals, and a family history of blood disorders.

Types of Myeloproliferative Disorders

  1. Polycythemia Vera (PV): Characterized by an overproduction of red blood cells, leading to thickened blood and an increased risk of clots.
  2. Essential Thrombocythemia (ET): Involves the overproduction of platelets, which can lead to abnormal blood clotting or bleeding.
  3. Myelofibrosis (MF): A condition where the bone marrow is replaced with scar tissue, leading to anemia, fatigue, and an enlarged spleen.

Symptoms of Myeloproliferative Disorders

Symptoms vary depending on the type of MPD, but common signs include:

  • Fatigue and weakness
  • Shortness of breath
  • Frequent infections
  • Easy bruising or bleeding
  • Unexplained weight loss
  • Bone pain or joint discomfort
  • Enlarged spleen or liver

Diagnosis of Myeloproliferative Disorders

Diagnosing Myeloproliferative Disorders typically involves:

  • Blood Tests: To check for elevated levels of red blood cells, white blood cells, or platelets.
  • Bone Marrow Biopsy: To examine the bone marrow for abnormal cell production.
  • Genetic Tests: To identify mutations such as the JAK2 gene mutation.

Treatment Options for Myeloproliferative Disorders

Treatment plans for MPDs depend on the specific type, severity, and symptoms of the disorder:

  • Medications: To reduce blood cell production, such as hydroxyurea or interferon-alpha.
  • Phlebotomy: Regular removal of blood to reduce red blood cell count in Polycythemia Vera.
  • Low-dose Aspirin: To reduce the risk of blood clots.
  • Targeted Therapy: Drugs like ruxolitinib are used to target specific genetic mutations.
  • Bone Marrow Transplant: In severe cases, a bone marrow or stem cell transplant may be necessary.

Cost of Treatment and Stay in India

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