Dr Rahul Bhargava Haematologist

MBBS, MD, DM (Clinical Haematology)

Principal Director & Chief Hematology at Fortis Hospital

MBBS, MD, DM (Clinical Haematology)

Principal Director & Chief Hematology at Fortis Hospital

Thrombocytosis

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Frequently Asked Questions (FAQ) :

Primary thrombocytosis is due to intrinsic blood cell production issues, while secondary thrombocytosis is a reaction to another condition or factor.

Regular blood tests and follow-up appointments with Dr. Rahul Bhargava are essential to monitor platelet levels and adjust treatment as needed.

Primary thrombocytosis may require ongoing management, while secondary thrombocytosis often resolves once the underlying condition is treated.

Adopting a healthy diet, exercising regularly, and avoiding smoking can help manage the condition effectively.

What is Thrombocytosis?

Thrombocytosis is a condition characterized by an unusually high number of platelets in the blood. Platelets are crucial for blood clotting, but when their levels exceed normal ranges, it can lead to health complications. Thrombocytosis can be categorized into different types based on its cause and nature.

Causes of Thrombocytosis

Primary (Essential) Thrombocytosis:

  • Genetic Mutations: This type is often caused by genetic mutations in the JAK2, CALR, or MPL genes, leading to uncontrolled platelet production.
  • Chronic Myeloproliferative Disorders: These are blood cancers where there is an overproduction of blood cells, including platelets.

Secondary (Reactive) Thrombocytosis:

  • Infections: The body may increase platelet production in response to infections.
  • Inflammatory Diseases: Conditions like rheumatoid arthritis or inflammatory bowel disease can trigger elevated platelet counts.
  • Iron Deficiency: Low iron levels can lead to a reactive increase in platelet production.
  • Recent Surgery or Trauma: Platelet counts may rise temporarily as part of the healing process following surgery or injury.

Types of Thrombocytosis

  1. Primary (Essential) Thrombocytosis:
  • Description: A chronic condition where the bone marrow produces excessive platelets without a known secondary cause.
  • Characteristics: Often associated with genetic mutations and can lead to complications like blood clots or bleeding.
  1. Secondary (Reactive) Thrombocytosis:
  • Description: An elevated platelet count resulting from another underlying condition or factor.
  • Characteristics: Typically resolves once the underlying cause, such as an infection or iron deficiency, is treated.

Symptoms of Thrombocytosis

Many individuals with thrombocytosis may not experience noticeable symptoms. However, some potential symptoms include:

  • Headaches
  • Dizziness
  • Vision problems
  • Tingling or numbness in the extremities
  • Chest pain
  • Unexplained bleeding or bruising

Diagnosis of Thrombocytosis

Dr. Rahul Bhargava will use the following methods to diagnose thrombocytosis:

  • Blood Tests: A complete blood count (CBC) to measure platelet levels.
  • Bone Marrow Biopsy: To evaluate the production of blood cells and identify abnormalities.
  • Genetic Testing: To detect mutations associated with primary thrombocytosis.
  • Additional Tests: To rule out secondary causes, such as iron studies or inflammatory markers.

Treatments for Thrombocytosis

Treatment options vary based on the type and severity of thrombocytosis:

  • Medications:
    • Aspirin: To help reduce the risk of blood clots.
    • Hydroxyurea: To lower platelet counts in primary thrombocytosis.
    • Anagrelide: Another medication used to control high platelet levels.
  • Platelet Apheresis: A procedure to remove excess platelets from the bloodstream.
  • Treatment of Underlying Conditions: For secondary thrombocytosis, addressing the root cause, such as treating an infection or correcting iron deficiency, is essential.
  • Lifestyle Adjustments: Maintaining a healthy lifestyle can support overall blood health.

Cost of Treatment and Stay in India

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